Carcinogenic effects of N-nitroso-3-(substituted phenylimino)-indolin-2-one derivatives
نویسندگان
چکیده
منابع مشابه
Synthesis and biological evaluation of 3-substituted-indolin-2-one derivatives containing chloropyrrole moieties.
Eighteen novel 3-substituted-indolin-2-ones containing chloropyrroles were synthesized and their biological activities were evaluated. The presence of a chlorine atom on the pyrrole ring was crucial to reduce cardiotoxicity. The presence of a 2-(ethyl-amino)ethylcarbamoyl group as a substituent at the C-4' position of the pyrrole enhanced the antitumor activities notably. IC50 values as low as ...
متن کامل3-(Phenylimino)indolin-2-one
The imino C=N double bond in the title compound, C(14)H(10)N(2)O, exists in an E conformation, with the phenyl ring being twisted by 80.7 (1)° in one independent mol-ecule and by 81.4 (1)° in the other with respect to the plane of the indoline fused-ring system. The two independent mol-ecules are linked by N-H⋯O hydrogen bonds, forming a zigzag chain running along the a axis.
متن کامل3-(Diphenylmethylidene)indolin-2-one
The title mol-ecule, C(21)H(15)NO, has an indoline-2-one and two benzene substituent groups which are arranged in a propeller-like fashion around the central C atom. The dihedral angle between the two benzene rings is 73.32 (16)° and those between the benzene rings and the indoline-2-one group are 76.54 (14) and 67.69 (14)°. In the crystal, there is an inter-molecular N-H⋯O hydrogen-bonding int...
متن کامل3-[(E)-Benzylidene]indolin-2-one
In the title indolin-2-one derivative, C(15)H(11)NO, the phenyl ring and the oxoindoline fused-ring system (r.m.s. deviation = 0.011 Å) are aligned at 48.52 (6)°. In the crystal, inversion-related mol-ecules form an N-H⋯O hydrogen-bonded dimer via an eight-membered {⋯HNCO}(2) synthon. The dimeric aggregates are linked into a three-dimensional architecture via C-H⋯O and π-π inter-actions between...
متن کامل3-(4-Hydroxyphenylimino)indolin-2-one
In the title compound, C(14)H(10)N(2)O(2), the dihedral angle between the indole and benzene rings is 61.63 (4)°. In the crystal structure, centrosymmetrically related mol-ecules are linked into dimers by N-H⋯O hydrogen bonds, generating rings of graph-set motif R(2) (2)(8). The dimers are further connected into a three-dimensional network by O-H⋯O and C-H⋯O hydrogen bonds.
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ژورنال
عنوان ژورنال: Journal of Pharmacy and Bioallied Sciences
سال: 2012
ISSN: 0975-7406
DOI: 10.4103/0975-7406.99035